Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Prochlorperazine Mesilate

Form: Injection 12.5mg/ml

Indication

Vertigo, Psychoses, Nausea and vomiting, Severe anxiety disorders

Administration

May be taken with or without food.

Adult Dose

IV/IM: Nausea and vomiting Adult: As mesilate: 12.5 mg by deep IM. If required, may give further doses via oral admin. Psychoses Adult: As mesilate: 12.5-25 mg by deep IM Inj bid/tid. Oral Prophylaxis of nausea and vomitting Adult: As mesilate: 5-10 mg bid/tid. May also be given rectally. Nausea and vomiting Adult: As mesilate: 20 mg, further doses are given if needed. Recommended buccal dose: As maleate: 3-6 mg bid. Psychoses Adult: As mesilate: 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily. Adjunct in severe anxiety disorders Adult: As mesilate: 5-10 mg, up to 3-4 times daily. Vertigo Adult: As mesilate: 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended buccal dose: 3-6 mg bid.

Child Dose

Psychoses Child: 1-5 yr: 1.25-2.5 mg; 5-12 yr: 2.5-5 mg. May be given up to tid, if necessary.

Contraindication

CNS depression, comatose patients. Bone marrow depression, phaechromocytoma, prolactin-dependent tumours, hypersensitivity. Childn <2 yr. Pregnancy and lactation.

Mode of Action

Antiemetic: Antidopaminergic effect, blocking dopamine receptors in the brain, blocking vagus nerve in GI tract. Antipsychotic: Blocking mesolimbic dopamine receptors, and blocking alpha-adrenergic receptors (D1 and D2) in brain.

Introduction

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Uses of __NAME__

{'list': ['Nausea', 'Vomiting', 'Vertigo', 'Meniere's disease', 'Schizophrenia']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Drowsiness', 'Orthostatic hypotension (sudden lowering of blood pressure on standing)']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken with food.

How __NAME__ works

__NAME__ is a dopamine antagonist. It works by blocking the dopamine receptors in the region of brain that controls nausea and vomiting.

Safety Advice

It is unsafe to consume alcohol with __NAME__.

Safety Advice

Information regarding the use of __NAME__ during pregnancy is not available. Please consult your doctor.

Safety Advice

__NAME__ is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Occasional short-term use of __NAME__ for the treatment of nausea and vomiting poses little risk to the breastfed infant.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.