Pack size: 1 Tablet  |  Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Sofosbuvir

Form: Tablet 400mg

Indication

Chronic Hepatitis C, Patients with hepatocellular carcinoma awaiting liver transplantation

Administration

Should be taken with food.

Adult Dose

Oral Chronic Hepatitis C One 400 mg tablet taken once daily with or without food - Should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC. Recommended combination therapy: (HCV Mono-infected and HCV/HIV-1 Co-infected ) Genotype 1 or 4 : Sofosbuvir + Peginterferon alfa + Ribavirin for 12 weeks Genotype 2: Sofosbuvir + Ribavirin for 12 weeks Genotype 3: Sofosbuvir + Ribavirin for 24 weeks - Sofosbuvir in combination with Ribavirin for 24 weeks can be considered for CHC patients with genotype 1 infection who are Interferon ineligible - Should be used in combination with Ribavirin for treatment of CHC in patients with hepatocellular carcinoma awaiting liver transplantation for up to 48 weeks or until liver transplantation whichever occurs first - A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease

Child Dose

Safety and efficacy not established

Contraindication

When Sofosbivur is used in combination with Ribavirin or Peginterferon alfa/Ribavirin, the contraindications applicable to those agents are applicable to combination therapies. Sofosbuvir combination treatment with Ribavirin or Peginterferon alfa/Ribavirin is contraindicated in women who are pregnant or may become pregnant and men whose female partners are pregnant, because of the risks for birth defects and fetal death associated with Ribavirin.

Mode of Action

Nucleotide prodrug that undergoes metabolism to the active uridine analog triphosphate, an inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition in turn suppresses viral replication .

Introduction

__NAME__ is an antiviral medication. It is used along with other medications for the treatment of chronic hepatitis C virus (HCV) infection. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time. __NAME__ should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. It should be taken with food, preferably at a fixed time. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. It has fewer side effects as compared to other similar medicines, like fatigue, headache, nausea, insomnia (difficulty sleeping) and anemia (low red blood cell count). Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.

Uses of __NAME__

{'list': ['Chronic hepatitis C virus (HCV) infection']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Fatigue', 'Nausea', 'Headache', 'Insomnia (difficulty in sleeping)', 'Anemia (low number of red blood cells)']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken with food.

How __NAME__ works

__NAME__ is an antiviral medication. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__, when taken together with other medicines for the treatment of hepatitis c infection, may produce dizziness, blurred vision and this may affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with severe kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Limited information is available on use of __NAME__ in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Safety Advice

__NAME__ is safe to use in patients with liver disease. No dose adjustment of __NAME__ is recommended.