Relexid

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Detail Description

Pack size: 1 Tablet | Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Pivmecillinam

Form: Tablet 200mg

Indication

Acute uncomplicated cystitis, Chronic or recurrent bacteriuria

Adult Dose

Oral Acute uncomplicated cystitis Adult: Initially 400 mg followed by 200 mg tid for 8 doses. Chronic or recurrent bacteriuria Adult: 400 mg 3-4 times daily.

Child Dose

Oral Acute uncomplicated cystitis Child: <40 kg with UTI: 20-40 mg/kg/day in 3-4 divided doses. Chronic or recurrent bacteriuria Child: <40 kg with UTI: 20-40 mg/kg/day in 3-4 divided doses.

Contraindication

Hypersensitivity, porphyria.

Mode of Action

Pivmecillinam has the antimicrobial activity of mecillinam to which it is hydrolysed in vivo. It interferes with the synthesis of bacterial cell wall. It is active against many gm-ve bacteria, esp Enterobacteriaceae including Escherichia coli, Enterobacter, Klebsiella, Salmonella and Shigella spp; indole-positive Proteus and Serratia marcescens are resistant. It is inactivated by beta-lactamases, but is more stable than ampicillin.

Precaution

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum K concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. May cause oesophageal injury.