Pack size: 1 Tablet  |  Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Rofecoxib

Form: Tablet 12.5mg

Indication

Osteoarthritis, Rheumatoid arthritis, Pain

Adult Dose

Oral Osteoarthritis Adult: Initially, 12.5 mg once daily. Max: 25 mg/day. Pain relief Adult: Initially, 50 mg once daily followed by daily doses of 25-50 mg. Max: 50 mg/day. Treatment duration >5days is not recommended. Rheumatoid arthritis Adult: 25 mg daily. Max: 25 mg/day. Hepatic Impairment Max: 12.5 mg/day.

Contraindication

Hypersensitivity. Severe renal impairment.

Mode of Action

Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of (rofecoxib) is believed to be due to inhibition of prostaglandin synthesis, via inhibition of cyclooxygenase-2 (COX-2).

Precaution

Hepatic dysfunction, pregnancy and lactation. History of ulcer disease or GI bleeding. Elderly or debilitated patients. Prolonged treatment, smoking and alcoholism may increase risk of GI bleeding. Ischaemic heart disease.

Side Effect

Mouth ulcers, chest pain, weight gain, atopic eczema, muscle cramps, diarrhoea, headache, nausea; upper respiratory tract infection, hypertension, ischaemia, dyspepsia, epigastric discomfort, heart burn, nausea, sinusitis, back pain, headache, bronchitis, urinary tract infections. Potentially Fatal: Renal failure; nephrotoxicity; MI.

Introduction

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Uses of __NAME__

{'list': ['Pain relief']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Flu-like symptoms', 'Peripheral edema']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).

Safety Advice

It is unsafe to consume alcohol with __NAME__.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

Information regarding the use of __NAME__ during breastfeeding is not available. Please consult your doctor.

Safety Advice

It is not known whether __NAME__ alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Safety Advice

There is limited information available on the use of __NAME__ in patients with kidney disease. Please consult your doctor. Use of __NAME__ is not recommended in patients with severe kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with moderate to severe liver disease.