Pack size: Strip of 10 Tablets  |  Price is for the whole Strip

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Bosentan

Form: Tablet 62.5mg

Indication

Pulmonary Arterial Hypertension (PAH)

Administration

Bosentan should be administered in the morning and evening with or without food.

Adult Dose

Oral Pulmonary hypertension Adult: >12 yr <40 kg: Initial and maintenance dose is 62.5 mg bid; >40 kg: Initially, 62.5 mg bid for 4 wk, then increased to a maintenance dose of 125 mg bid. Elderly: No dosage adjustment needed. Hepatic impairment: Mild: No dosage adjustment needed. Moderate and severe: Contraindicated.

Renal Dose

Renal impairment: No dosage adjustment needed in renal impairment or dialysis patients.

Contraindication

Patients with WHO Class II symptoms showed reduction in the rate of clinical deterioration and a trend for improvement in walk distance. Physicians should consider whether these benefits are sufficient to offset the risk of hepatotoxicity in WHO Class II patients, which may preclude future use as their disease progresses.

Mode of Action

Competitive antagonist of endothelin-1; blocks endothelin receptors on vascular endothelium and smooth muscle resulting in inhibition of vasoconstriction

Introduction

$4c

Uses of __NAME__

{'list': ['Pulmonary arterial hypertension (PAH)']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Headache', 'Ankle swelling', 'Edema (swelling)', 'Diarrhea', 'Anemia (low number of red blood cells)', 'Respiratory tract infection']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. __NAME__ helps relax these blood vessels and increases the supply of blood to the lungs.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

__NAME__ may cause excessive drowsiness with alcohol.

Safety Advice

__NAME__ is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Safety Advice

__NAME__ is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. As __NAME__ can induce hypotension (decrease of your blood pressure) which can make you feel dizzy and this can affect your ability to drive.

Safety Advice

__NAME__ is safe to use in patients with kidney disease. No dose adjustment of __NAME__ is recommended.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with moderate and severe liver disease.