Pack size: 1 Tablet  |  Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Doxylamine + Pyridoxine

Form: Tablet 10mg+10mg

Indication

Nausea & Vomiting of Pregnancy

Administration

Take on empty stomach with water; food further delays onset of action and lowers peak levels Swallow tablet whole, do not chew, crush, or split

Adult Dose

Oral Nausea & Vomiting of Pregnancy Indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management Delayed-release Tablet 2 delayed-release tablets PO on a daily basis at bedtime If symptoms not adequately controlled, increase dose to 4 tablets each day (1 tab in AM, 1 tab mid-afternoon, and 2 tabs at bedtime) Conventional Tablet Initially, take one tablet orally at bedtime (Day 1). If this dose adequately controls symptoms the next day, continue taking one tablet daily at bedtime only. If symptoms persist, increase the daily dose to one tablet in the morning and one tablet at bedtime. The maximum recommended dose is two tablets per day, one in the morning and one at bedtime.

Child Dose

<18 years: Safety and efficacy not established

Contraindication

Hypersensitivity MAO inhibitors intensify and prolong doxylamine’s adverse effects (ie, anticholinergic, CNS)

Mode of Action

Doxylamine: Ethanolamine derivative antihistamine Pyridoxine: Vitamin B6 analog Doxylamine is an antihistamine that blocks Histamine (H1) receptor. It affects the vestibular system and decreases the stimulation of the vomiting center. Its mascarinic receptor inhibition may also play a role in antihistamine antiemetic activity. Pyridoxine (Vitamin B6) is a vitamin used to prevent nausea and vomiting due to its antiemetic properties.

Introduction

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Uses of __NAME__

{'list': ['Nausea and vomiting in pregnancy']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Dryness in mouth', 'Constipation', 'Lightheadedness', 'Drowsiness']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is a combination of two medicines: Doxylamine and vitamin B6 (pyridoxine), which treats nausea and vomiting associated with pregnancy. Doxylamine is an antihistamine which works by blocking the action of a chemical messenger (histamine), thereby controlling nausea, vomiting, and dizziness. Pyridoxine (vitamin B6) is a form of vitamin B which possesses anti-nausea properties.

Safety Advice

Caution is advised when consuming alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Larger doses or prolonged use of __NAME__ may cause sleepiness and other effects in the baby

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.

Safety Advice

__NAME__ is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.