Pack size: Strip of 10 Tablets  |  Price is for the whole Strip

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Acyclovir

Form: Tablet 200mg

Indication

Oral Primary herpes simplex infections Adult: 200 mg 5 times daily every 4 hr for 5-10 days; for severely immuno compromised patients and those with impaired absorption: 400 mg 5 times daily for 5 days. Suppression of recurrent herpes simplex Adult: 800 mg daily in 2-4 divided doses. May reduce to 400-600 mg daily if necessary. Reassess the condition every 6-12 mth. For mild or infrequent recurrences: Episodic treatment may be used: 200 mg 5 times daily for 5 days, preferably begun during the prodromal period. Prophylaxis of herpes simplex in immunocompromised patients Adult: 200-400 mg 4 times daily. Varicella zoster 800 mg 5 times/day for 5-7 days. Herpes zoster 800 mg 5 times/day for 7-10 days.

Administration

Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).

Adult Dose

Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Drug enters breast milk; use with caution.

Renal Dose

Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.

Contraindication

Child: PO 900 mg/m2/day q8h 60–80 mg/kg/day (max 4 g/day) q6–8h Varicella Zoster (Chickenpox) >2 years and <40 kg: 20 mg/kg/dose PO q6hr for 5 days; not to exceed 800 mg/dose >10 mL/min/1.73 m²: 200 mg q4hr (five times daily) 400 mg every 12 hr 0-10 mL/min/1.73 m²: 200 mg q12hr >10 mL/min/1.73 m²: 400 mg q12hr 800 mg every 4 hr 0-10 mL/min/1.73 m²: 800 mg q12hr 10-25 mL/min/1.73 m²: 800 mg q8hr >25 mL/min/1.73 m²: 800 mg q4hr (five times daily)

Mode of Action

May be taken with or without food. May be taken w/ meals to reduce GI discomfort. Reconstitution: Add 10 mL or 20 mL of sterile water for inj to a vial labeled as containing 500 mg or 1,000 mg of aciclovir, respectively, to provide a soln containing 50 mg/mL. The appropriate dose of reconstituted soln should then be withdrawn from the vial and diluted w/ 50-125 mL of a compatible IV infusion soln.

Introduction

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Uses of __NAME__

{'list': ['Herpes simplex virus infections', 'Chickenpox', 'Herpes labialis', 'Shingles', 'Genital herpes infection']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Headache', 'Dizziness', 'Vomiting', 'Nausea', 'Fatigue', 'Fever', 'Stomach pain', 'Diarrhea', 'Skin rash', 'Photophobia']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Safety Advice

__NAME__ is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Safety Advice

__NAME__ does not usually affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. It is advisable to drink plenty of water while you are taking this medicine.

Safety Advice

__NAME__ is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.