It is indicated in the vitamin B-Complex deficiency states like beriberi, Wernicke's encephalopathy, loss of appetite, cheilosis, glossitis, angular stomatitis, keratitis, seborrhoeic dermatitis, pellagra, photophobia, peripheral neuritis, corneal vascularization, in conditions causing depletion, or ... Read more

It is indicated in the vitamin B-Complex deficiency states like beriberi, Wernicke's encephalopathy, loss of appetite, cheilosis, glossitis, angular stomatitis, keratitis, seborrhoeic dermatitis, pellagra, photophobia, peripheral neuritis, corneal vascularization, in conditions causing depletion, or reduced absorption of vitamins such as gastrointestinal disorders, chronic alcoholism, febrile illness, prolonged or wasting diseases, hyperthyroidism or poorly controlled diabetes, and conditions resulting in increased requirement for B-Complex vitamins e.g. pregnancy, severe burns and recovery from surgery.

Dosage & Administration

Tablet and Capsule: 1-2 tablets/capsules thrice daily.

Syrup: 2-3 teaspoonful daily or as directed by the physician.

Injection: It is used when the oral route is not feasible or when rapid correction of vitamin B-group is needed. It can be given intramuscularly or intravenously (slowly) in a dose of 2 mL daily or as advised by the Registered Physician.

Interaction

Pyridoxine may increase the peripheral metabolism of levodopa, reducing therapeutic efficacy in patients
with Parkinson's disease.

Contraindications

Hypersensitivity to any of its components.

Side Effects

Adverse reactions have been reported with specific vitamins, and generally at levels substantially higher
than those in Orabex. However, allergic and idiosyncratic reactions are possible at lower levels.

Precautions & Warnings

It should be given cautiously to patients taking levodopa as pyridoxine reduces the effect of levodopa. Hypersensitivity may develop in patients previously given thiamine, specially after repeated injections of concentrated solution; give subsequent injections with care. Discontinue drug if untoward reactions develop. Intramuscular administration may cause transient pain; when used undiluted, administer slowly.

Therapeutic Class

Specific combined vitamin preparations

Storage Conditions

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.