Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Polymyxin B Sulfate

Form: injection 500000/Unit

Indication

Susceptible infections, Meningitis

Administration

IV/IM/IT Preparation IV: dilute 500,000 U in 300-500 mL D5W IM: reconstitute vial with 2 mL SWI , NS, or procaine HCl 1% solution Intrathecal (IT): reconstitute vial with10 mL NS; DO NOT use procaine HCl for IT IV/IM Administration IV: infuse over 60-90 min IM: give deep into upper outer quadrant of gluteal muscles

Adult Dose

Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max: 2,000,000 U/day. Intramuscular Susceptible infections Adult: 25,000-30,000 U/kg daily in divided doses 4-6 hrly. Max: 2,000,000 U/day. Intrathecal Meningitis Adult: 50,000 U once daily for 3-4 days, then on alternate days for at least 2 wk after CSF cultures are negative and CSF glucose content is normal. Max: 2,000,000 U/day.

Child Dose

Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max: 2,000,000 U/day. Child: <2 yr 40,000 U/kg daily in divided doses 12 hrly; ?2 yr Same as adult dose. Intramuscular Susceptible infections Child: <2 yr 40,000 U/kg daily in divided doses 6 hrly (not routinely recommended due to pain at injection sites); >2 yr Same as adult dose but not routinely recommended due to pain at injection sites. Intrathecal Meningitis Child: <2 yr 20,000 U once daily for 3-4 days or 25,000 U on alternate days, followed by the latter dose for at least 2 wk after CSF cultures are negative and CSF glucose content is normal; >2 yr Same as adult dose.

Renal Dose

Renal Impairment CrCl >20 mL/minute: give 75-100% usual dose/day divided q12hr CrCl 5-20 mL/minute: give 50% usual dose/day divided q12hr CrCl <5 mL/minute: give 15% usual dose/day q12hr

Contraindication

Hypersensitivity to polymyxins; Concurrent use w/ nephrotoxic and/or neurotoxic drugs and neuromuscular blockers.