Pack size: Strip of 8 Capsules  |  Price is for the whole Strip

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Lenvatinib Mesylate

Form: Capsule 4mg

Indication

Patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated, thyroid cancer. In combination with everolimus for the treatment of patients with, advanced renal cell carcinoma, following 1 prior vascular endothelial growth factor-targeted therapy.

Administration

Swallow capsule whole May take with or without food Take at the same time each day

Adult Dose

Adult Differentiated thyroid cancer (DTC) 24 mg once daily. Renal cell carcinoma (RCC) 18 mg in combination w/ everolimus 5 mg once daily. Patient w/ severe hepatic impairment Initially 14 mg once daily for DTC. 10 mg once daily for RCC.

Renal Dose

Patient w/ severe renal impairment Initially 14 mg once daily for DTC. 10 mg once daily for RCC.

Contraindication

Hypersensitivity. Lactation.

Mode of Action

Receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4) Also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet-derived growth factor receptor alpha (PDGFR-alpha), KIT, and RET

Introduction

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Uses of __NAME__

{'list': ['Thyroid cancer'], 'tag': ''}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Bleeding', 'Cough', 'Decreased appetite', 'Erythema (skin redness)', 'Hoarseness of voice', 'Itching', 'Joint pain', 'Mouth sore', 'Muscle pain', 'Nausea', 'Peripheral edema', 'Rash', 'Skin peeling', 'Stomach pain', 'Tiredness', 'Vomiting', 'Weight loss']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is a tyrosine kinase inhibitor. It works by blocking the oxygen and nutrient supply to cancer cells due to which they stop growing.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Safety Advice

It is not known whether __NAME__ alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.