Pack size: 1 200 metered dose  |  Price is for the whole 200 metered dose

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Ipratropium Bromide + Salbutamol

Form: inhaler 20mcg+100mcg/puff

Indication

Chronic obstructive pulmonary disease, Asthma

Adult Dose

Inhalation Chronic obstructive pulmonary disease Adult: Inhalation: 100 mcg/20 mcg (1 actuation of metered-dose inhaler) q6hr; not to exceed 6 actuations/day Nebulizer solution: Initially, 3 ml every 6 hr. Max: 3 ml every 4 hr. One ampoule as required for the relief of symptoms or as directed. Up to three to four ampoules daily.

Child Dose

Safety and efficacy not established

Contraindication

The combination of Salbutamol & Ipratropium Bromide is contraindicated in patients with hypertrophic obstructive cardiomyopathy and tachyarrhythmia and in patients with a history of hypersensitivity to atropine or its derivatives, or to any other component of the product.

Mode of Action

Ipratropium bromide is an anticholinergic agent that inhibits vagally-mediated reflexes by antagonising the action of acetylcholine. It prevents the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) which are brought about by interaction of acetylcholine with the muscarinic receptors on bronchial smooth muscle. Salbutamol is a direct-acting beta 2-adrenergic agent. It acts on the airway smooth muscle resulting in bronchodilation.

Precaution

May cause paradoxical bronchospasm. Caution when used in patients who are sensitive to sympathomimetic agents. Caution when used in patients with CV disease as beta-agonists may increase BP, heart rate and risk of arrhythmias. Monitor blood glucose in diabetics. Monitor serum potassium levels especially in patients who are on concurrent treatment with xanthine derivatives, steroids or diuretics. Caution when used in patients with narrow angle glaucoma, hyperthyroidism, prostatic hyperplasia, bladder neck obstruction, seizure disorders, renal or hepatic impairment. Safety and efficacy have not been established in children <12 yr. Increased risk of GI motility disturbance in patients with cystic fibrosis. Pregnancy and lactation. Lactation: Unknown whether drug is excreted in breast milk

Introduction

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Uses of Combimist-L Respules

{'list': ['Chronic obstructive pulmonary disease (COPD)']}

Side effects of Combimist-L Respules

{'tag': 'Common', 'list': ['Dryness in mouth', 'Breathlessness', 'Cough', 'Tremor', 'Headache', 'Palpitations', 'Muscle cramp']}

How to use Combimist-L Respules

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Twist off the top of the respule/transpule and squeeze all the liquid into the nebulizer. It should be used right away after opening.

How Combimist-L Respules works

__NAME__ is a combination of two medicines: Salbutamol/Albuterol and Ipratropium. Salbutamol/Albuterol is a bronchodilator while Ipratropium is an anticholinergic. They work by relaxing the muscles in the airways and widen the airways. Together, they make breathing easier.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safety Advice

No interaction found/established

Safety Advice

No interaction found/established

Safety Advice

No interaction found/established