Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Degarelix

Form: Injection 80mg

Indication

Hormone-dependent Advanced Prostate Carcinoma (Stage D)

Administration

Initiation pack contains 2 vials each with 120 mg per vial & 6 mL sterile water for injection diluent Withdraw 3 mL of sterile water for injection diluent (supplied) & add to 1 of the 2 vials, swirl to mix - keep vial vertical at all times, do not shake Inject SC in abdomen within 1 hour of reconstitution Repeat for 2nd injection and use different injection site Maintenance pack contains 1 vial of 80 mg per vial & 4.2 mL sterile water for injection diluent Use 4.2 mL to reconstitute, withdraw 4 mL for dose of 80 mg

Adult Dose

Subcutaneous Advanced prostate cancer Adult: Loading dose: As 40 mg/mL solution: 240 mg (given as 2 separate injections of 120 mg). Maintenance: As 20 mg/mL solution: 80 mg once every 28 days, starting 28 days after the initial dose. Doses are administered in the abdominal area. Hepatic Impairment Mild-to-moderate: Dose adjustment not necessary Severe: Safety and efficacy not established; use caution

Renal Dose

Renal Impairment >50 mL/min: Dose adjustment not necessary <50 mL/min: Use caution

Contraindication

Hypersensitivity. Pregnancy and lactation.

Mode of Action

Degarelix, a synthetic decapeptide, reversibly and competitively binds to gonadotropin-releasing hormone (GnRH) receptors in the anterior pituitary gland, thereby decreasing secretion of luteinising hormone (LH) and follicle stimulating hormone (FSH), and subsequently reducing testicular androgen synthesis.

Introduction

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Uses of __NAME__

{'list': ['Prostate cancer']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Injection site reactions (pain, swelling, redness)', 'Weight gain', 'Hot flashes', 'Increased liver enzymes', 'Low sexual desire', 'Erectile dysfunction']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ lowers the amount of testosterone (a male hormone) produced by the body. This may slow or stop the spread and growth of prostate cancer cells that need testosterone to grow.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, please consult your doctor.

Safety Advice

Caution is advised when consuming alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Safety Advice

Information regarding the use of __NAME__ during breastfeeding is not available. Please consult your doctor.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

There is limited information available on the use of __NAME__ in patients with kidney disease. Please consult your doctor. A cautious use of __NAME__ is advised in patients with severe kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with severe liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. No dose adjustment is recommended for patients with mild to moderate liver disease. Regular monitoring of testosterone levels is advised.