Pack size: 1 250mg vial  |  Price is for the whole 250mg vial

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: 5-Fluorouracil (5-FU)

Form: Injection 250mg/10ml

Indication

Palliation of malignant neoplasms, Superficial basal cell carcinoma, Oesophageal carcinoma, Carcinoma of Colon, Carcinoma of Breast, Carcinoma of Ovary, Carcinoma of Liver, Carcinoma of Pancreas, Carcinoma of Rectum, Carcinoma of Stomach

Administration

IV Preparation IV Push: dose/syringe (concentration: 50 mg/mL); max syringe size for IVP is 30 mL syringe and syringe should be <75% full Continuous IV Infusion/IVPB: dose/50-1000 mL D5W or NS; syringe and solution are stable for 72 hr at 4 to 25°C IV Administration Direct IV push injection (50 mg/mL solution needs no further dilution) or by IV infusion Toxicity may be reduced by giving the drug as a constant infusion Bolus doses may be administered by slow IVP or IVPB Warm to body temperature before using Continuous IV infusion may be administered in D5W or NS Solution should be protected from direct sunlight 5-FU may also be administered intra-arterially or intra-hepatically Use plastic IV containers for continuous infusions (stable in plastic IV bags than in glass bottles)

Adult Dose

Adult: IV Palliation of malignant neoplasms 12 mg/kg/day (max: 0.8-1g/day) for 3-4 days, if no toxicity occurs, may be followed after 1 day w/ 6 mg/kg on alternate days for another 3-4 doses. May repeat course 4-6 wk later or maintenance doses of 5-15 mg/kg (max: 1 g) may be given wkly. Cancers of Colon, Breast, Ovary, Liver, Pancreas, Rectum, Stomach Various protocols exist 500 mg/sq.meter IV on Days 1-5, OR 450-600 mg/sq.meter IV weekly, OR 200-400 mg/sq.meter IV continuous infusion qD Not to exceed 800 mg/day As an infusion: 15 mg/kg/day (max: 1 g/day), continue until toxicity occurs or a total of 12-15 g is given. May repeat course 4-6 wk later. Intra-arterial Palliation of malignant neoplasms 5-7.5 mg/kg/day as continuous infusion (regional perfusion). Hepatic impairment: Dose reduction may be required.

Child Dose

Child: Safety & efficacy not established.

Renal Dose

Renal impairment: Dose reduction may be required.

Contraindication

Topical application on mucous membranes, exposure to sunlight, hypersensitivity. Depressed bone marrow function, poor nutritional status, potentially serious infections. Pregnancy and lactation.

Introduction

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Uses of __NAME__

{'list': ['Cancer']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Increased risk of infection', 'Mouth ulcer', 'Vomiting', 'Weakness', 'Nausea', 'Loss of appetite', 'Hair loss', 'Blisters on fingers/feet', 'Decreased blood cells (red cells, white cells, and platelets)', 'Diarrhea']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__ can cause side effects such as nausea and can also produce adverse events on your nervous system which cause visual changes.This may affect your ability to drive.

Safety Advice

__NAME__ is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.