Dimis 50/200

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Detail Description

Pack size: 1 Tablet | Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Diclofenac Sodium + Misoprostol

Form: Tablet 50mg+200mcg

Indication

Rheumatoid arthritis, Osteoarthritis, Joint and muscular pains

Administration

Swallow tablet whole, do not chew or crush Do not take with antacids

Adult Dose

Osteoarthritis 50 mg/200 mcg, 75mg/200mcg: 1 tab PO three times daily; not to exceed 200 mcg misoprostol/dose or 800 mcg/day Rheumatoid Arthritis 50 mg/200 mcg, 75mg/200mcg: 1 tab PO three or four times daily; not to exceed 200 mcg misoprostol/dose or 800 mcg/day If not tolerated may reduce frequency to twice daily Three times daily dose of misoprostol is more protective than when given twice daily

Child Dose

Safety & efficacy not established

Contraindication

Diclofenac Sodium and Misoprostol combination is contraindicated in women who are pregnant because of the abortive property of the Misoprostol component.

Mode of Action

Diclofenac: Inhibits cyclooxygenase-1 (COX-1) & -2 (COX-2), thereby inhibiting prostaglandin synthesis; has anti-inflammatory, antipyresis, and analgesic properties. Misoprostol: Replaces protective prostaglandins consumed by prostaglandin-inhibiting therapies (NSAID-induced ulcers).