Pack size: 1 Tablet  |  Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Deferasirox

Form: Tablet 250mg

Indication

Chronic iron overload.

Administration

Should be taken on an empty stomach. Take on an empty stomach at least 30 min before meals preferably at the same time daily. Disperse tab completely by stirring in 100-200 mL of water/apple juice/orange juice until a fine susp is obtained; consume entire content. Rinse the glass w/ a little water/juice to resuspend any residue & drink remainder. Do not disperse tab in fizzy drinks/milk. Do not chew/ break/crush tab or swallow whole. Do not take w/ Al-containing antacids.

Adult Dose

Transfusional Hemosiderosis Indicated for treatment of chronic iron overload caused by blood transfusion 20 mg/kg PO qDay; may increase by 5-10 mg increments based on serum ferritin; if not controlled on 30 mg/kg/day (ie, serum ferritin persistently >2500 mcg/L), may increase up to 40 mg/kg qDay Nontransfusion-Dependent Thalassemia Indicated for treatment of chronic iron overload caused by nontransfusion-dependent thalassemia syndromes and with a liver iron (Fe) concentration (LIC) of at least 5 mg Fe per gram of dry weight (dw) and a serum ferritin >300 mcg/L 10 mg/kg PO qDay (calculate dose to nearest tablet size); if LIC >15 mg Fe/g dw after 4 weeks, consider increasing dose to 20 mg/kg/day Hepatic Impairment Mild (Child-Pugh A): No dose adjustment required Moderate (Child-Pugh B): Decrease initial dose by 50% Severe (Child-Pugh C): Avoid use

Child Dose

Transfusional Hemosiderosis Indicated for treatment of chronic iron overload caused by blood transfusion <2 years: Safety and efficacy not established 20 mg/kg PO qDay; may increase by 5-10 mg increments based on serum ferritin; if not controlled on 30 mg/kg/day (ie, serum ferritin persistently >2500 mcg/L), may increase up to 40 mg/kg qDay Nontransfusion-Dependent Thalassemia Indicated for treatment of chronic iron overload caused by nontransfusion-dependent thalassemia syndromes and with a liver iron (Fe) concentration (LIC) of at least 5 mg Fe per gram of dry weight (dw) and a serum ferritin >300 mcg/L <10 years: Safety and efficacy not established 10 mg/kg PO qDay (calculate dose to nearest tablet size); if LIC >15 mg Fe/g dw after 4 weeks, consider increasing dose to 20 mg/kg/day

Renal Dose

Renal Impairment Baseline renal impairment CrCl 40-60 mL/min: Reduce starting dose by 50% Serum Cr >2 xULN or CrCl <40 mL/min: Do not use

Contraindication

Hypersensitivity.

Introduction

__NAME__ is a medicine used in the treatment of chronic iron overload caused by frequent blood transfusion. It helps remove the excess iron from the body and reduce the risk of it causing organ damage. __NAME__ should be taken in empty stomach. Take it regularly at a fixed time each day to get the maximum benefit of the medicine. Using of __NAME__ may cause common side effects such as nausea, headache, constipation, diarrhea and increased liver enzyme. If the side effects persist or worsen, inform your doctor.

Uses of __NAME__

{'list': ['Iron overload', 'Transfusion dependent thalassemia']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Nausea', 'Headache', 'Vomiting', 'Rash', 'Abdominal pain', 'Constipation', 'Itching', 'Increased liver enzymes', 'Abdominal distension', 'Diarrhea']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken empty stomach.

How __NAME__ works

__NAME__ traps and removes excess iron which is then excreted mainly in the stools. This reduces the risk of organ damage.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Limited information is available on the use of __NAME__ in these patients.