Pack size: 1 Capsule  |  Price is for the whole Capsule

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Danazol

Form: Capsule 100mg

Indication

Endometriosis, Benign breast disorders, Gynaecomastia, Hereditary angioedema, Menorrhagia.

Administration

May be taken with or without food. Take consistently either always w/ or always w/o meals.

Adult Dose

Oral Endometriosis Adult: 200-800 mg daily in 2 divided doses adjusted according to response, for 3-6 mth or if necessary, up to 9 mth. Benign breast disorders Adult: Initially, 100-400 mg daily in 2 divided doses adjusted according to response and continued for 3-6 mth. Gynaecomastia Adult: Male adolescents: Initially, 200 mg daily, may increase to 400 mg daily after 2 mth if no response occurs; adult men: Initial: 400 mg daily in up to 4 divided doses. Usual treatment duration: 6 mth. Child: Male adolescents: Initially, 200 mg daily increased to 400 mg after 2 mth if no response occurs. Treatment usually up to 6 months. Hereditary angioedema Adult: Initially, 200 mg bid-tid reduced thereafter according to patient's response. Preoperative thinning of the endometrium Adult: 400-800 mg daily, in up to 4 divided doses for 3-6 wk. Menorrhagia Adult: 200 mg once daily. Review treatment 3 mth later.

Contraindication

Hypersensitivity, pregnancy, lactation, porphyria, thromboembolic disorders; undiagnosed genital bleeding, markedly impaired renal, cardiac or hepatic dysfunction.

Mode of Action

Danazol suppresses the pituitary-ovarian axis by reducing the release of follicle-stimulating hormone and luteinizing hormone. This causes the regression and atrophy of endometrial tissue, decreases growth rate of abnormal breast tissue and reduces attacks in hereditary angioedema.

Precaution

Danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. Since hepatic dysfunction manifested by modest increases in serum transaminases levels has been reported in patients treated with Danazol, periodic liver function tests should be performed Administration of danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyria. Lactation: enters breast milk/contraindicated

Introduction

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Uses of __NAME__

{'list': ['Heavy menstrual bleeding', 'Endometriosis', 'Benign fibrocystic breast disease']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Hoarseness of voice', 'Hair loss', 'Weight gain', 'Acne', 'Abnormal hair growth on a women face and body', 'Voice change', 'Itchy scalp', 'Swelling', 'Sore throat']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ modulates the action of certain female hormones in the body.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

It is unsafe to consume alcohol with __NAME__.

Safety Advice

__NAME__ is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__ may cause some side effects such as dizziness, a spinning feeling, and changes in eyesight. This may affect your driving ability.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ may not be advised in patients with severe kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with the severe liver disease. Regular monitoring of liver function tests is advised while you are taking this medicine.