Pack size: 1 Injection  |  Price is for the whole Injection

Generic: Amoxicillin + Clavulanic Acid (Clavulanate)

Indication

Adults: PO: One 375 mg tablet 3 times a day. In severe infection one 625mg tablet 3 times a day or one 1gm tablet two times a day. IV Injection: 1.2 g every 6-8 hours Hepatic impairment: Dose with caution; monitor hepatic function regularly

Administration

Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.

Adult Dose

History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment. Lactation: Drug excreted in breast milk; use caution

Renal Dose

Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.

Contraindication

Children: 125/31.25-, 250/62.5-mg/5-mL susp: 20–40 mg amoxicillin component/kg/day (max 1,500 mg/day) q8h 200/28.5-, 400/57-mg/5-mL susp: 25-45 mg amoxicillin component/kg/day (max 1,750 mg/day) q12h Children of 6-12 years: 2 teaspoonful Powder for Suspension every 8 hours. Children of 1-6 years: 1 teaspoonful Powder for Suspension every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours. Children over 12 years: IV Injection: 1.2 g every 6-8 hours, Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants); Child 3 months-12 years, 30 mg/kg every 6-8 hours.

Mode of Action

Take with meals to avoid GI upset Take suspension at start of meal to enhance absorption Reconstitution: Powd for inj: Dissolve amoxicillin/clavulanic acid 500/100 mg in 10 mL solvent and 1,000/200 mg in 20 mL solvent. May further dilute to infusion soln containing either water for inj or NaCl 0.9%.

Introduction

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Uses of __NAME__

{'list': ['Bacterial infections']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Vomiting', 'Nausea', 'Diarrhea']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken with food.

How __NAME__ works

__NAME__ is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Amoxycillin against bacteria.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

Consuming alcohol with __NAME__ does not cause any harmful side effects.

Safety Advice

__NAME__ is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Safety Advice

__NAME__ is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__ may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of this medicine is not recommended in patients with severe kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Regular monitoring of liver function tests is recommended while you are taking this medicine