Pack size: 1 20ml vial  |  Price is for the whole 20ml vial

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Tocilizumab

Form: IV Infusion 400mg/20ml

Indication

Juvenile idiopathic arthritis, Rheumatoid Arthritis (RA)

Administration

IV Preparation Withdraw a volume of 0.9% NaCl from bag/bottle equal to volume of the solution required for the patient's dose Adults and children weighing >30 kg: Dilute to 100 mL in 0.9% NaCl Children <30 kg: Dilute to 50 mL in 0.9% NaCl Slowly add dose to infusion bag or bottle and gently invert to mix (prevent foaming) IV Administration Administer as single IV infusion over 1 hr Do NOT administer as bolus or push Do not infuse with any other drugs as no compatibility studies have been conducted SC Preparation Remove prefilled SC syringe from refrigerator 30 minutes before administration SC Administration Indicated only in adults with rheumatoid arthritis Rotate SC injection sites (ie, thighs, abdomen, outer area of upper arm [caregiver only]) and inject full amount of the syringe (0.9 mL) Transition from IV to SC: Administer first SC dose instead of next scheduled IV dose

Adult Dose

Parenteral Adult: Rheumatoid Arthritis Indicated for adults with moderate-to-severe active rheumatoid arthritis with inadequate response to 1 or more DMARDs as an IV infusion or SC injection May use alone or in combination with methotrexate or other DMARDs IV infusion 4 mg/kg IV q4wk initially; may increase to 8 mg/kg q4wk based on clinical response Not to exceed 800 mg/dose q4wk SC injection Weight <100 kg: 162 mg SC every other week, followed by an increase to every week based on clinical response Weight >100 kg: 162 mg SC every week Hepatic impairment Not recommended with active hepatic disease or hepatic impairment

Child Dose

Systemic Juvenile Idiopathic Arthritis (SJIA, Still's Disease) <2 years: Safety and efficacy not established >2 years or older (<30 kg): 12 mg/kg IV q2weeks (>30 kg): 8 mg/kg IV q2weeks May be administered as monotherapy or with methotrexate Polyarticular Juvenile Idiopathic Arthritis (PJIA) <2 years: Safety and efficacy not established >2 years or older (<30 kg): 10 mg/kg IV q4weeks (>30 kg or more): 8 mg/kg IV q4weeks May be administered as monotherapy or with methotrexate

Renal Dose

Renal impairment Mild: No dosage adjustment required Moderate-to-severe: Has not been studied

Contraindication

Hypersensitivity

Introduction

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Uses of __NAME__

{'list': ['Ankylosing spondylitis', 'Rheumatoid arthritis', 'Psoriasis', 'Ulcerative Colitis', 'Crohn’s disease']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Headache', 'High blood pressure', 'Upper respiratory tract infection', 'Increased liver enzymes', 'Nasopharyngitis (inflammation of the throat and nasal passages)']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain joint diseases.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, please consult your doctor.

Safety Advice

Consuming alcohol with __NAME__ does not cause any harmful side effects.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Limited information is available on the use of __NAME__ in patients with moderate to severe kidney disease. No dose adjustment is required in patients with mild kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with active liver disease.